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Endometriome Screening Test

Screening test for intrauterine microbial environment

TheEndometriome is a screening test that provides information on the intrauterine microbial environment. Indeed, there is an important relationship between the endometrial microbiota andembryonic implantation.

Specifically, in the presence of dysbiosis, or pathogenic bacteria, alteration of the endometrial microbiota may hinder the onset of pregnancy or be the cause of a miscarriage. The most prevalent endogenous bacterial species is lactobacillus.

An important example of a disease caused by alteration of the endometrial microbiota is chronic endometritis (CE).
EC is characterised by a persistent inflammatory process in the endometrium and is generally asymptomatic or in some cases may be present with non-specific symptoms such as abnormal uterine bleeding, pelvic pain or malodorous flow.

It is estimated that in 39% of reproduction failures, the woman is affected by EC, up to 60% in women with recurrent miscarriages (RPL) and 66% in women with repeated unsuccessful attempts to become pregnant.


It is a genetic screening test to assess the uterine microbial environment, specifically the optimum characteristics that allow embryo implantation.
The endometriome can be carried out on a sample of endometrial tissue or fluid, taken at our clinic, between days 15 and 25 of the menstrual cycle or during the endometrial secretory phase in hormone replacement therapy (HRT) treatments.
Subsequently, the test involves a genetic analysis using Next Generation Sequencing (NGS) performed by the GENOMA molecular genetics laboratory in Rome and, if necessary, appropriate corrective treatment.

NGS analysis provides:

  • - an accurate and complete profile of endometrial microbiota;
  • - the percentage of lactobacillus in the endometrial microbiota. If the report suggests dysbiosis, or the presence of pathogens, appropriate corrective treatment can be proposed;
  • - the possibility for the specialist to make an informed choice about when it is appropriate to transfer the embryo;
  • - information on pathogenic bacteria causing EC in order to propose appropriate antibiotic treatment.

Applications and suitability of the Endometriome

The Endometriome is useful:

  • - in patients with repeated embryo implantation failures.
  • - in all childbearing patients in order to assess the presence of undiagnosed dysbiosis or chronic endometritis that could negatively interfere with embryo implantation
  • - in patients with recurrent miscarriages.