Specifically, in the presence of dysbiosis, or pathogenic bacteria, alteration of the endometrial microbiota may hinder the onset of pregnancy or be the cause of a miscarriage. The most prevalent endogenous bacterial species is lactobacillus.
An important example of a disease caused by alteration of the endometrial microbiota is chronic endometritis (CE).
EC is characterised by a persistent inflammatory process in the endometrium and is generally asymptomatic or in some cases may be present with non-specific symptoms such as abnormal uterine bleeding, pelvic pain or malodorous flow.
It is estimated that in 39% of reproduction failures, the woman is affected by EC, up to 60% in women with recurrent miscarriages (RPL) and 66% in women with repeated unsuccessful attempts to become pregnant.
It is a genetic screening test to assess the uterine microbial environment, specifically the optimum characteristics that allow embryo implantation.
The endometriome can be carried out on a sample of endometrial tissue or fluid, taken at our clinic, between days 15 and 25 of the menstrual cycle or during the endometrial secretory phase in hormone replacement therapy (HRT) treatments.
Subsequently, the test involves a genetic analysis using Next Generation Sequencing (NGS) performed by the GENOMA molecular genetics laboratory in Rome and, if necessary, appropriate corrective treatment.
NGS analysis provides:
The Endometriome is useful: